Intestine: Internal or External organ?
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Zonulin as marker of Inflammatory Bowel diseases
Zonulin as consequence of Gut Dysbiosis
Zonulin is a modulator of both epithelial and endothelial barrier functions and its role in health and disease remains an object of active research. Gut dysbiosis may cause the release of zonulin leading to the passage of luminal contents across the epithelial barrier causing the release of pro-inflammatory cytokines that themselves cause increased permeability establishing a vicious loop leading to massive influx of dietary and microbial Ags triggering the activation of T cells.
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PMA-zeolite and Zonulin: read article
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